Read more about the science behind NewJoint:
1. Cissus Quadrangularis
Cissus quadrangularis is a vining plant in the grape family found in India which has been used for medicinal purposes for millennia in traditional Ayurvedic medicine. While the natural remedy has been applied to a wide variety of illnesses, Cissus quadrangularis is best known for its uses on bone and in pain control.(1) Studies have shown that Cissus quadrangularis reduces fracture healing time(2,3) and also prevents experimentally-induced osteoporosis.(4,5) These effects are thought to be due to the product’s ability to enhance the proliferation, differentiation, and mineralization of human bone-creating cells (human osteoblast-like SaOS-2 cells),(6) presumably by augmenting local growth factors.(7) Multiple in vitro and animal studies have suggested extracts of Cissus quadrangularis may protect the types of cells found in the stomach and from the damage that common pain killers (NSAIDs) cause.(8-12) This property is thought to be related to an immunomodulating effect and antioxidant activity. Animal research suggests Cissus quadrangularis possesses pain relieving, anti-inflammatory properties.(13) NewJoint contains optimum levels of highly purified cissus quadrangularis extract for maximum strength.
1. Stohs SJ, Ray SD. A review and evaluation of the efficacy and safety of Cissus quadrangularis extracts. Phytother Res 2012.
2. Udupa KN, Prasad GC. FURTHER STUDIES ON THE EFFECT OF CISSUS QUADRANGULARIS IN ACCELERATING FRACTURE HEALING. Indian J Med Res 1964;52:26-35.
3. Udupa KN, Prasad GC. Cissus quadrangularis in healing of fractures. A clinical study. J Indian Med Assoc 1962;38:590-3.
4. Banu J, Varela E, Bahadur AN, Soomro R, Kazi N, Fernandes G. Inhibition of Bone Loss by Cissus quadrangularis in Mice: A Preliminary Report. J Osteoporos 2012;2012:101206.
5. Potu BK, Nampurath GK, Rao MS, Bhat KM. Effect of Cissus quadrangularis Linn on the development of osteopenia induced by ovariectomy in rats. Clin Ter 2011;162:307-12.
6. Muthusami S, Senthilkumar K, Vignesh C, et al. Effects of Cissus quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS-2 cells. J Cell Biochem 2011;112:1035-45.
7. Muthusami S, Ramachandran I, Krishnamoorthy S, Govindan R, Narasimhan S. Cissus quadrangularis augments IGF system components in human osteoblast like SaOS-2 cells. Growth Horm IGF Res 2011;21:343-8.
8. Jainu M, Devi CS. Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: role of proinflammatory cytokines and oxidative damage. Chem Biol Interact 2006 ;161(3):262-70.
9. Jainu M, Mohan KV. Protective role of ascorbic acid isolated from Cissus quadrangularis on NSAID induced toxicity through immunomodulating response and growth factors expression. Int Immunopharmacol 2008;8(13-14):1721-7.
10. Jainu M, Mohan KV, Devi CS. Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats. J Ethnopharmacol. 2006 Apr 6;104(3):302-5.
11. Jainu M, Devi CS. Effect of Cissus quadrangularis on gastric mucosal defensive factors in experimentally induced gastric ulcer-a comparative study with sucralfate. J Med Food. 2004 Fall;7(3):372-6.
12. Jainu M, Mohan KV. Protective role of ascorbic acid isolated from Cissus quadrangularis on NSAID induced toxicity through immunomodulating response and growth factors expression. Int Immunopharmacol. 2008 Dec 20;8(13-14):1721-7.
13. Panthong A, Supraditaporn W, Kanjanapothi D. Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn. J Ethnopharmacol. 2007 Mar 21;110(2):264-70.
2. Avocado Unsaponifiables
Avocado unsaponifiables, which are the highly oily extracts of avocado oils, have gained recent research interest in the field of osteoarthritis and joint health. Popularly recommended by physicians in Europe, this natural product appears to help patients manage osteoarthritis symptoms, with some patients finding they need less NSAID pain killers to for their osteoarthritis related pain when taking avocado unsaponifiables.(1-5) One proposed mechanism of this joint comforting effect is that avocado unsaponifiables are able to preserve joint cartilage by reducing the damage caused by inflammation.(6) The extract may also work by up-regulating glycosaminoglycan and collagen synthesis, which are important in joint structure and integrity.(7) Moreover, avocado unsaponifiables may reduce pain by blocking COX-2 expression and prostaglandin E2 production.(8) NewJoint uses ultra high quality Avocado unsaponifiables in effective dosage quantities for maximum benefit.
1. Appelboom T, Schuermans J, Verbruggen G, Henrotin Y, Reginster JY. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study. Scand J Rheumatol 2001;30:242-7.
2. Blotman F, Maheu E, Wulwik A, Caspard H, Lopez A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Rev Rhum Engl Ed 1997;64:825-34.
3. Christensen R, Bartels EM, Astrup A, Bliddal H. Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage 2008;16:399-408.
4. Lequesne M, Maheu E, Cadet C, Dreiser RL. Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip. Arthritis Rheum 2002;47:50-8.
5. Maheu E, Mazieres B, Valat JP, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect. Arthritis Rheum 1998;41:81-91.
6. Khayyal MT, el-Ghazaly MA. The possible “chondroprotective” effect of the unsaponifiable constituents of avocado and soya in vivo. Drugs Exp Clin Res 1998;24:41-50.
7. Lippiello L, Nardo JV, Harlan R, Chiou T. Metabolic effects of avocado/soy unsaponifiables on articular chondrocytes. Evid Based Complement Alternat Med 2008;5:191-7.
8. Heinecke LF, Grzanna MW, Au AY, Mochal CA, Rashmir-Raven A, Frondoza CG. Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate. Osteoarthritis Cartilage 2010;18:220-7.
Cholecalciferol, or vitamin D3, is critically important in bone metabolism (formation and remodeling). Cholecalciferol is essential for the proper absorption of calcium from the diet. When cholecalciferol levels are low, it may lead to osteopenia and osteoporosis.(1) Of the various ways to supplement vitamin D, cholecalciferol is preferred.(2) The prevalence of low vitamin D has increased recently and many people may have a deficiency and not realize it which is called a subclinical vitamin D deficiency.(3) This can lead to increased bone fracture risk as well as muscle weakness.(3) For osteoporosis treatment cholecalciferol supplementation alone may be sufficient to prevent falls and fractures.(6) Research suggests cholecalciferol may enhance bone mineral density in individuals with osteoarthrtitis.(7) The International Osteoporosis Foundation recommends vitamin D blood levels of 30 ng/ml for adults over age 60.8 The Harvard School of Public Health states: “Taking a vitamin D supplement of 800 to 1,000 IU per day will help people, on average, achieve adequate blood levels of vitamin D (30 ng/mL). These vitamin D amounts are safe”.(9) NewJoint provides 1000IU of bioidentical cholecalciferol per day to support optimal joint health.
1. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006;81:353-73.
2. van den Bergh JP, Bours SP, van Geel TA, Geusens PP. Optimal use of vitamin D when treating osteoporosis. Curr Osteoporos Rep 2011;9:36-42.
3. Pramyothin P, Holick MF. Vitamin D supplementation: guidelines and evidence for subclinical deficiency. Curr Opin Gastroenterol 2012;28:139-50.
4. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997;337:670-6.
5. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of withdrawal of calcium and vitamin D supplements on bone mass in elderly men and women. Am J Clin Nutr 2000;72:745-50.
6. Jackson C, Gaugris S, Sen SS, Hosking D. The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis. QJM 2007;100:185-92.
7. Bischoff-Ferrari HA, Zhang Y, Kiel DP. Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis. Arthritis Rheum. 2005 Dec 15;53(6):821-6.
8. Dawson-Hughes B, Mithal A, Bonjour JP, et al. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int. 2010. 21:1151-4.
9. Harvard School of Public Health. 2012. The Nutrition Source: Vitamin D and Health.